The mechanisms of itch:Why itch ?

What is itching ?

Itch was defined by Samuel Hafenreffer as "an unpleasant sensation that elicits the desire or reflex to scratch".

The important thing is "reflex".

The reflex scratches unconsciously.

Unconsciousness difficult to bear. And very very much!!

I know. I will be not scratched.

I noticed it after scratching.

Very troublesome…

There are 4 causes  of itching

1. Originates from the skin

Itching caused by skin , for example atopic eczema, dry skin, psoriasis, hives or other inframmatory skin diseases.

2. Neuropathic itch, cause by nerve damage

For example such as itch associated with post-herpes zoster neuropathy.

3. Neurogenic itch, caused by dysfunction of the nervous system in the absence of peripheral neuropathy

4. Psychological or psychiatric itching

I wrote a difficult thing about itching.

There is only one thing you want to know about itching.

Itching is caused not only by skin but also by nerves.

What is the itching mechanism?

"itch-specific receptors and identification of subsets of dorsal horn neurons"

Research on itching has just begun, the cause of itching is not known.

The cause of itching has not been identified, but there are several treatment.

So, I will find cure for itching that you suits.

If you are suffering from itch consult Miyako Internal Medicine.

Thank you for reading.

Citation Paper

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

Tong Liu and Ru-Rong Ji

Itch is light pain ?

It is Miyako Internal Medicine Clinic who is treating itching.

Itch and pain are both irritated.

The irritated sometimes interferes with daily activities.

Itching can be suppressed with a strong stimulus like pain.

Pain = Itch ?

Morphine is known to suppress pain, morphine can provoke itch.

A medicine that suppresses pain cause itching.

Itch elicits scratching response, wheres pain causes withdrawal responses.

So pain and itch are different symptoms.

"As one of the best studied itch mediators, histamine is released from mast cells and binds to histamin H1 receptor (H1R), which is coupled with Gαq, phospholipase Cβ3, and TRPV1 in DRG neurons to evoke itch. "

I explained the cause of itching difficultly.

There are many medicines for pain, but are there medicines for itching?

A part of itching mechanism was discovered in 2007.

The history of itching research is shallow.

There are few hospitals that treats itching.

Therefore, people suffering from itching comes from  Miyako Internal Medicine Clinic a long way.

Thank you for reading.

Citation paper

Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms?

Author:Ru-Rong Ji

Why are you concerned about rough skin?

The causes of itching is in Japan is said  to be sensitive skin.

How about the world?

"fragile skin"

Sensitive skin and fragile skin are similar.

Epidemiology of "fragile skin":results from a survey of different skin types

In response to the question “In your opinion, do you have fragile skin?”, 24.44%, 29.71%, 52.67%, and 42.20% of subjects in the Caucasian North, Caucasian South, Asian, and Black skin type groups, respectively, responded positively. Of the subjects responding positively, most were females; at least one in three women consistently provided a positive response

To positiviely answer , I think that I am interested in skin.

I think that the opportunity to take pictures with smartphones has increased as the reason for more interested in skin care.

Indeed, surpraised myself shot by smartphone.

Supraised to see the photos!!

This,me?？　I do not want to admit.

There were not many people who came consulting me in a panic.

Regardless of skin type, among patients with perceived “fragile skin” there was a consistently larger number of individuals who reported having experienced a skin disease in the last 12 months

When skin roughness occurs, skin becomes concerned.

I can see my skin and I can see it from people.

Let you notice rough skin before your family become careful.